Copy number variations (CNV) of KDM genes on chromosomes were displayed in Fig. 1D. Based on CNV frequency (Fig. 1E) and RNA expression of KDM genes (Fig. 1F) in paired tumor-normal tissues, KDM2A, KDM4A, KDM5B and KDM3A were upregulated in tumor, consistent with their CNV amplification. The gene discussed is KDM2A; the disease is neoplasm.