Copy number variations (CNV) of KDM genes on chromosomes were displayed in Fig. 1D. Based on CNV frequency (Fig. 1E) and RNA expression of KDM genes (Fig. 1F) in paired tumor-normal tissues, KDM2A, KDM4A, KDM5B and KDM3A were upregulated in tumor, consistent with their CNV amplification. This evidence concerns the gene KDM5B and neoplasm.