Although Notch1 loss of function mutations are commonly found in HNSCC (including in the two cell lines in this study), components of the Notch pathway have also been reported by others to be overexpressed in a subset of HNSCC patients suggesting a potential oncogenic role of Notch signaling in at least some cases of HNSCC. The gene discussed is NOTCH1; the disease is head and neck squamous cell carcinoma.