Using forward 2SMR, we observed evidence of causality (adjusted p<0.001 or unadjusted p<0.05) between type 2 diabetes and lower levels of DNAm at the CpGs cg20812370 (PBX1) (p=0.002) and cg01577083 (RBFOX1) (p=0.023) (Fig. 3, ESM Figs 1 and 2, ESM Methods S7). Here, PBX1 is linked to type 2 diabetes mellitus.