For four of the top six CpGs previously identified in a meta-EWAS of type 2 diabetes that had bidirectional 2SMR data (CpGs in TXNIP, HDAC4, SYNM and ABCG1), the observational and causal effects were consistent only at HDAC4 (cg00144180). This evidence concerns the gene TXNIP and type 2 diabetes mellitus.