Interestingly, USP28 counteracts the activity of the F-box and WD repeat domain containing protein 7 (FBXW7), a tumour suppressor protein that is part of the SCF (Skp1, Cullin-1, F-box) protein complex and facilitates the ubiquitination and destabilisation of MYC among other proteins. The gene discussed is FBXW7; the disease is neoplasm.