Furthermore, Krt5high/Ttf-1low lesions from a CRISPR-based lung cancer model driven by oncogenic activation of Kras together with deletion of Tp53 and Lkb1 (KPL) representing squamous tumours displayed increased levels of HMGCS1 expression compared to tumours mapping to the ADC subtype. Here, HMGCS1 is linked to neoplasm.