At the end of follow-up, insulin sensitivity improved in patients in whom prediabetes reverted and remained stable in those with persistent prediabetes: 0.09 [0.08–0.11] versus 0.04 [0.01–0.07], p = 0.001 (Stumvoll index, Table 1 and Fig. 2); 6.5 [6.0–12] versus 2.8 [2.4–5.3], p = 0.002 (Matsuda index, Table 1). The gene discussed is INS; the disease is prediabetes syndrome.