Those genes with moderate to high risk hereditary cancer susceptibility include homologous recombination repair genes BRCA2, BRCA1, CHEK2, ATM, PALB2, RAD51D; mismatch repair genes MLH1, MSH2, MSH6, PMS2; and pathogenic variant HOXB13. These genes are implicated in a range of cancer types, with the exception of HOXB13 which, to date, seems to be prostate cancer specific [12]. The gene discussed is PALB2; the disease is prostate cancer.