FASN and neoplasm: For examples, Fasn knockdown leads to accumulation of malonyl-CoA, thereby causing lysine 1218 malonylation on mTOR and impeding mTOR complex 1 kinase activity.5Fasn knockout delays hepatocarcinogenesis driven by sgPten/c-Met-driven in mice.6 Inhibition of fatty acid or sphingolipid synthesis leads to suppression of tumor development.7 But the applications to control FASN for cancer therapeutic efficacy remains largely unexplored.