For examples, upon phosphorylation of c-MYC by GSK3β kinase, FBXW7 recognized and degraded c-MYC.24 FBXW7 is a tumor suppressor54 that recognizes and degrades a series of oncoproteins, such as c-MYC, c-JUN, Cyclin E, MTOR, Aurora B, Notch, MCL-1, FOXO4 and CHD6.23–35 Therefore, it makes sense that the tumor suppressive E3 ligase FBXW7β causes degradation of a potential oncoprotein FASN. The gene discussed is FOXO4; the disease is neoplasm.