Further, fatty acid synthase can mediate EGFR palmitoylation, resulting in tyrosine kinase inhibitor (TKI) resistance in lung cancer.48 Our studies showed that CSN6-FASN axis increase palmitate production, implying that CSN6 may increase EGFR palmitoylation and possibly causes TKI-drug resistance. This evidence concerns the gene COPS6 and lung carcinoma.