Previous studies have shown that CSN6 is involved in the process of promoting colorectal malignancy.8 To determine the role of FASN in CSN6-promoted proliferation of CRC cells, we analyzed cellular growth of CSN6-expressing cells in the presence of FASN inhibitor orlistat (an FDA-approved anti-obesity drug). This evidence concerns the gene COPS6 and obesity due to melanocortin 4 receptor deficiency.