First, analysis of protein abundance of CSN6 and FASN in one normal colon cell line (HCEC) and ten selected FBXW7β-wild type (wt) CRC cell lines indicated that CSN6 and FASN levels were elevated in various CRC cell lines and that their expression was positively correlated (Supplementary Fig. 5a–c, Supplementary Table 2). The gene discussed is COPS6; the disease is colorectal carcinoma.