COPS6 and neoplasm: CSN6 KD leads to inhibition of cell growth and tumor volume, but additional CSN6 (shRNA resistant)-reexpression rescued this impact caused by CSN6 KD as demonstrated by promoting cell growth and increasing tumor volume (Fig. 6f, Supplementary Fig. 4f), enhancing tumor bioluminescent intensity (Fig. 6g), and increasing final tumor weight (Fig. 6h).