For examples, Fasn knockdown leads to accumulation of malonyl-CoA, thereby causing lysine 1218 malonylation on mTOR and impeding mTOR complex 1 kinase activity.5Fasn knockout delays hepatocarcinogenesis driven by sgPten/c-Met-driven in mice.6 Inhibition of fatty acid or sphingolipid synthesis leads to suppression of tumor development.7 But the applications to control FASN for cancer therapeutic efficacy remains largely unexplored. This evidence concerns the gene FASN and cancer.