PQBP1 and neurodegenerative disease: Tau protein, which is known to be involved in the pathogenesis of various neurodegenerative diseases, including AD and tauopathy, was found to activate microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation, such as TNF, IL-6 and type 1 IFN (Jin et al., 2021).