PQBP1 interacts with many proteins, including the U5 snRNP-specific 15 kDa protein (U5–15 kDa) and WBP11/NpwBP/SIPP1, and the KD or KO structure can significantly affect protein synthesis and is expected to be the next cellular therapeutic target for neurological diseases, viral infection and cancer (Mizuguchi et al., 2014). This evidence concerns the gene PQBP1 and cancer.