Although FKBP10, a peptidyl-prolyl-cis-trans-isomerase FK506-binding protein, has been reported as a potential cancer-related therapeutic target with a key biological role in tumor growth of NSCLC cells,14 the specific data on FKBP10 protein expression and its clinicopathological significance in NSCLC brain metastases remains unclear. The gene discussed is FKBP10; the disease is non-small cell lung carcinoma.