CYP11B2 and hypertensive disorder: Identified as the most cause of monogenic hypertension, this is an autosomal dominant inherited trait due to a chimeric gene duplication arising from unequal crossing over between the 5′ adrenocorticotropin-responsive regulatory sequences of 11β-hydroxylase (CYP11B1) gene to the 3′ coding sequences of aldosterone synthase (CYP11B2) gene.