Furthermore, in HBV-HCC patients, it was observed that Bacteroidota, Deferribacterota and CD3+T cells, Campilobacterota, Akkermaniacaeae and CD8+T cells, Actinobaciota and Treg cells, Actinobaciota, Myxococota and CD4+PD-1+T cells, Actinobacteriota and CD4+TEMRAcells at phylum level were positively correlated, while Gemmatimonadota and Fusobasteriota were negatively correlated with the percentage of Treg+PD-1+T cells (Figure 10A). The gene discussed is CD4; the disease is hepatocellular carcinoma.