In these 29 genes, seven (AURKB, BIRC5, CDCA8, CDH1, NR1H3, PPARA, and TOP2A) were correlated with the prognosis of kidney cancer through univariate cox regression analysis using the discovery TCGA cohort, and five genes (AURKB, CDCA8, CDH1, NR1H3, and PPARA) were selected from Lasso regression (Supplementary Figure S2). This evidence concerns the gene BIRC5 and kidney cancer.