In these 29 genes, seven (AURKB, BIRC5, CDCA8, CDH1, NR1H3, PPARA, and TOP2A) were correlated with the prognosis of kidney cancer through univariate cox regression analysis using the discovery TCGA cohort, and five genes (AURKB, CDCA8, CDH1, NR1H3, and PPARA) were selected from Lasso regression (Supplementary Figure S2). The gene discussed is CDCA8; the disease is kidney cancer.