Rosuvastatin blunts NASH-induced pro-inflammatory cytokine expression in livers from high-fat diet-fed STAM mice (378), while simvastatin reduces inflammation and fibrosis in Apoe−/− mice fed a high-fat, high-cholesterol diet for 7 weeks with corresponding inhibition of Ras and Rho signaling (379). The gene discussed is APOE; the disease is metabolic dysfunction-associated steatohepatitis.