GPT and metabolic dysfunction-associated steatohepatitis: Van den Hoek and colleagues fed Ldlr−/−.Leiden mice an obesogenic diet for 28 weeks containing 41% calories from fat, 0.05% cholesterol, and 44% calories from fructose (100), which recapitulated multiple aspects of NASH like inflammation (100), fibrosis (101), and circulating AST and ALT (102), as well as established atherosclerotic lesions (100).