In particular, SNPs in patatin-like phospholipase domain-containing protein 3 (PNPLA3), or transmembrane 6 super family 2 (TM6SF2) are known as strong predictors of NAFLD risk independent of associated metabolic confounding factors, despite these variants promoting lipotoxicity (383). Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.