Established biomarkers for CVD including C-reactive protein (CRP), cardiac troponins I and T, B-type natriuretic peptides, and D-dimer, are widely used for diagnosis and management of various CVDs including atherosclerosis, myocardial infarction, acute coronary syndrome, cardiac arrest, thrombosis, and ischemic cardiac diseases (142–144). This evidence concerns the gene CRP and acute coronary syndrome.