TJP1 and Abnormal intestine morphology: The observed mucosal barrier changes were similar to previous reports on AOM/DSS-induced enteropathy (Li et al., 2019; Oh et al., 2020; Luan et al., 2022), mainly featured by losing the expression of ZO-1 and occluding and blooming release of inflammatory factors, IL-1β and -IL6 (Figure 3).