Since LPS can stimulate TLR4, which leads to initial immune responses in enterocytes, the role of TLR4 mediating the development of colitis-associated tumorigenesis has been established in the aspects of enhancing direct recruitment of NF-κB and the large increase in cytokines (Park et al., 2009; Olona et al., 2021). This evidence concerns the gene TLR4 and colitis.