CDC50A and anemia (phenotype): In the same year, it was found that knocking out Tmem30a in mouse hematopoietic cells caused severe anemia in their embryos on day 16.5, resulting in embryonic death, and a decrease in the number of erythroid colonies and erythroid cells in the liver of the fatal embryo, which may be due to impaired localization of erythropoietin-stimulating erythropoietin receptors in membrane raft microregions in Tmem30a-deficient cells [44].