Also, the lack of Tmem30a reduced the activity of flippase, interfered with the phosphorylation of PKCζ, and affected FXRα and other signaling pathways related to bile synthesis and transport, resulting in a decrease in the level of BS transporter (organic anion-transporting polypeptide OATP1A4, OATP1B2, sodium-taurocholate cotransporting polypeptide NTCP, etc.), and, eventually, hyperbilirubinemia and hypercholesterolemia [53]. The gene discussed is SLC10A1; the disease is Hyperbilirubinemia.