TNFRSF1A and neoplasm: ,18 Expression of the Fas-TNFRs therefore creates a self-regulatable way to augment CAR T cell activation, irrespective of tumor FasL expression, whereby CAR activation (signals one and two) upregulates FasL surface expression, binding the Fas-TNFR on a sister CAR T cell, which delivers an additional third signal to the CAR T cell (Figure 7).