This extract also modulated the mitochondrial apoptotic pathwayby upregulating cytochrome c and Bax and downregulating Bcl-X (L).20 In HER2-positive breast cancer, solamarginedownregulated HER2/neu receptor, which is associated with growth andprogression of this malignancy.21 In lungcancer, solamargine inhibited cancer cell lines by downregulatingprostaglandin E2, DNA methyltransferase 1 (DNMT1) and c-Jun.22 This evidence concerns the gene ERBB2 and breast cancer.