A similar study found that acupuncture increased hippocampal MR expression in PTSD model animals while decreasing GR expression, increasing the MR/GR ratio (Hou et al., 2013b; Wang, 2019), implying that acupuncture may regulate damaged PTSD model hippocampal neurons, regulate the expression of MR and GR, and then affect the activity of the HPA axis. Here, NR3C1 is linked to post-traumatic stress disorder.