A study found that acupuncture increased the expression of C-Fos in the vmPFC in PTSD model animals and that vmPFC inactivation eliminated the effect of acupuncture on anxiety-like behavior in PTSD model animals, indicating that the vmPFC is involved in the process of electro-targeting PTSD anxiety (Hou et al., 2021; Yang et al., 2022). The gene discussed is FOS; the disease is post-traumatic stress disorder.