In addition, acupuncture treats PTSD by acting on the BDNF-TrkB pathway, Keap1-Nrf2 pathway, mTOR pathway, and other signaling pathways (Ding, 2018; Oh et al., 2018; Zhou et al., 2019; Li et al., 2020a,b). The gene discussed is NFE2L2; the disease is post-traumatic stress disorder.