MMP9 and acute myeloid leukemia: As exhibited in Figure 9(b), the concentrations of IL-2, IFN-γ, GZMB, and LAMP-1 were decreased in the AML model mice versus the control mice, while DC-CIK cells could memorably reserve the decreases in the AML model mice; in addition, we disclosed that the increases of IL-2, IFN-γ, GZMB, and LAMP-1 levels mediated by DC-CIK cells could be further enhanced by MMP9 or CCL1 knockdown in DC-CIK cells.