LRRK2 and Parkinson disease: Missense mutations along the leucine-rich repeat kinase2 (LRRK2)protein are a major contributor to Parkinson’s Disease (PD),the second most commonly occurring neurodegenerative disorder worldwide.We recently reported the development of allosteric constrained peptideinhibitors that target and downregulate LRRK2 activity through disruptionof LRRK2 dimerization.