CASP8 and infection: We next determined effects of imatinib on granuloma growth in ripk3-/-casp8-/+ and ripk3-/-casp8-/- mice infected with Mm and exposed to imatinib or water for 7 days either starting day -1, or day 7 p.i., for a total infection period of 6 or 14 days (Fig 8A).