Induction of discernable levels of cell death in BMDMs from ripk3-/-casp8-/+ or ripk3-/-casp8-/- required infection with Mm at an MOI of 10 rather than an MOI of 1 used in C57BL/6J BMDMs, though even at this MOI, the percentage of cells undergoing necrosis was still lower than in C57BL/6J cells (compare Fig 7C, 7E and 7F). Here, RIPK3 is linked to infection.