We applied SHINE to the analysis of TCGA Breast Cancer RNA-seq data to learn subtype-specific networks corresponding to the PAM50 molecular classification into Luminal A, Luminal B, HER2-enriched, and Basal-like (the Normal-like subtype was excluded because of too small a sample size, n = 40)[58]. The gene discussed is ERBB2; the disease is breast carcinoma.