The current study had the following goals: (a) assess the blood DDX43 protein and mRNA expression levels in benign and malignant BC patients compared to control subjects (b) evaluate the correlation between DDX43 protein levels and mRNA expression levels (c) investigate the possible relationships between both DDX43 protein, mRNA levels and clinicopathological characteristics (d) examine the potential interacting proteins with DDX43 protein via one of the commonly used protein-protein interaction databases. The gene discussed is DDX43; the disease is breast cancer.