NFE2L2 and neurodegenerative disease: NRF2 is implicated in neurodegenerative diseases, metabolic disorders, cancer, and chronic inflammatory disorders (43, 56, 80), leading to clinical efforts directed toward the modulation of NRF2 activity to promote a range of cytoprotective benefits, including redox homeostasis, dampening and resolution of inflammation, and suppression of fibrosis (81).