Additionally, after transfection of human and mouse sarcoma cell lines with artificially produced cGAMP or cGAMP analogues like DMXAA, in cells lacking Atrx, we identified a second deficiency in the CGAS/STING pathway that can be localized to a pathway component between STING and IFNB1 in the signaling cascade. This evidence concerns the gene CGAS and sarcoma.