To determine whether the observed reduction in Ifnb1 expression after radiation in our ATRX-deleted sarcomas was the result of an impairment in the CGAS/STING pathway, we first assessed the proficiency of the pathway in mouse sarcoma cell lines via CGAS/STING induction using interferon stimulatory DNA (ISD). This evidence concerns the gene IFNB1 and sarcoma.