Interestingly, recent reports have identified ATRX as an important modulator of the cyclic guanosine monophosphate-adenosine monophosphate synthase (CGAS) and its adaptor protein Stimulator of IFN Gene (STING) pathway’s response to extrachromosomal telomeric repeat DNA in cancer cell lines with alternative lengthening of telomeres (ALT) (15). The gene discussed is CGAS; the disease is cancer.