Such a mechanism occurs in Amyotrophic Lateral Sclerosis, a progressive NDD in which loss of function by nuclear-to-cytoplasmic mislocalization of TAR DNA binding protein 43 kDa (TDP-43) plays a major causative role (Atkinson et al. 2021; Suk and Rousseaux 2020). This evidence concerns the gene TARDBP and Neurodevelopmental delay.