By analyzing the TCGA cohort, we discovered that DLAT had a strong inverse association with the TME immune composition in 27 different cancers, namely ACC, BRCA, CESC, ESCA, GBM, GBMLGG, HNSC, LAML, LGG, LUAD, LUSC, MESO, KIPAN, KIRC, KIRP, PCPG, PRAD, SARC, SKCM, SKCM-M, SKCM-P, STAD, STES, TGCT, THCA, THYM, and UCEC, and inversely linked to the TME stromal component in 14 cancers, notably, ACC, CESC, ESCA, GBM, KIPAN, LUAD, LUSC, PCPG, SARC, SKCM-P, STAD, STES, THCA, and UCEC. The gene discussed is DLAT; the disease is cancer.