IL17A and hypertensive disorder: Nguyen et al. revealed a significant increase in phosphorylation of endothelial NO synthase residue threonine 495 (eNOSThr495) by IL-17 in cellular and mouse models and thus an increase in systolic blood pressure [108], accompanied by Li et al.'s identification of IL-17 as critical for EC senescence [109], implying that IL-17 is a mediator of the essential link between senescence and hypertension in ECs.