First, if a MEN1 VUS is revealed by germline sequencing, our findings indicate that loss of menin expression in at least two parathyroid tumors or the presence of other MEN1 syndrome pathognomonic tumors (eg, pituitary neuroendocrine tumors or gastropancreatic neuroendocrine tumor) may be an additional argument to consider the VUS as likely pathogenic. Here, MEN1 is linked to multiple endocrine neoplasia type 1.