Therefore, a genetic test is offered to patients who fulfill the clinical criteria for MEN1 syndrome, their families, patients with multigland hyperparathyroidism, or patients with a high suspicion of MEN1 syndrome.1 However, genetic testing is inconclusive in 5% to 25% of patients with a clinical diagnosis and in some patients with high suspicion of MEN1 syndrome.1,5 This is often due to the presence of a variant of unknown significance (VUS) in the MEN1 gene.1,9,12,13 For these patients, the diagnosis and prognosis of MEN1 syndrome remains uncertain. The gene discussed is MEN1; the disease is multiple endocrine neoplasia type 1.