Interestingly ApoE has profound effects on regulating Aβ metabolism, tau pathology, mitochondrial function, inflammation and other pathways that play a central role in AD pathogenesis [7, 9, 38, 40, 99, 101, 102] therefore it is suggested that ApoE isoforms may differentially influence AD initiation and progression pathways. This evidence concerns the gene MAPT and Alzheimer disease.