The role of CRP in the pathogenesis of AMD has been well established and also showed to be a prominent component of drusen in AMD patients [75].With this in mind both E3 and E4 recombinant proteins reduced levels of CCL2 in RPE cells treated with lipopolysaccharide (LPS), however more reduction was observed in E4 compared to that of E3 group. This evidence concerns the gene CCL2 and age-related macular degeneration.