Non-T2 asthma (also known as type 2-low-, or non-eosinophilic asthma) is a heterogeneous condition which may comprise several underlying mechanisms including the influx of CD4+ type 1 T helper (Th1) and type 17 T helper (Th17) cells, type 1 and type 3 innate lymphoid cells (ILC1 and ILC3 respectively), neutrophils as well as increased levels of pro-inflammatory mediators in the lung tissues, among others including IL-1ß, IL-6, IL-8, IL-17A/F, IL-22, IFN-γ, and TNF-α. This evidence concerns the gene CD4 and asthma.