Based on increased levels of inflammatory proteins and cytokine profiles, CRS (with and without NP) comprises three different endotypes, i.e., T1 characterised by type1 cytokines IFN-γ and TGF-β, T2 by type2 proteins and cytokines IgE and IL-4, IL-5, and IL-13, and T3 by Th17 cytokine IL-17A [77,80,81]. Here, IL5 is linked to congenital rubella syndrome.