We compared the study group with the gnomAD exomes v2.1 consisting of the genetic data of 125 748 individuals, which is comparable to the general population with a similar burden of cardiovascular disease.16,18 After filtering for MAF and protein-altering changes, 1649 rare TNNI3K alleles were identified in this cohort (1.3%). Here, TNNI3K is linked to cardiovascular disorder.