To this end, we turned to the UK Biobank, a population-based dataset with rich phenotypic data and exome sequencing on over 450 000 individuals.19 We performed gene-based burden testing of rare TNNI3K variants for 7 disease end points20 (atrial fibrillation [AF], SVT, SVT [excl. This evidence concerns the gene TNNI3K and atrial fibrillation.