ENAH and neoplasm: Metastasis promoting PvTAMs reside in what has been termed ‘Tumor MicroEnvironments of Metastasis’ (TMEM), which involves a PvTAM, tumor cell expressing a splice variant of mammalian-enabled protein ‘Mena’ referred to as Mena invasive (MenaINV), and an endothelial cell which are in direct contact.