TAM expression of CXCR4 is induced by tumor cell-derived transforming growth factor-β (TGF-β) which enables the migration of these TAMs to the endothelium which is orchestrated by Pv fibroblasts, phenotypically distinct from pericytes (desmin−), which express high levels of CXCL12 [6]. The gene discussed is CXCR4; the disease is neoplasm.