Therefore, as schematized in the diagram, FBXW11, acting on beta‐catenin, indirectly reduces RUNX2 levels in osteosarcoma cells, whose FBXW11 levels decrease following miR 221 overexpression, increased levels of both beta‐catenin and RUNX2 are observed. The gene discussed is RUNX2; the disease is osteosarcoma.