Since FBXW11 binds to its target proteins at phosphorylated sites to induce degradation,12, 37 the increased beta‐catenin in association with increased levels of FBXW11 suggests reduced phosphorylated beta‐catenin levels in CCD samples, emphasising the dysregulation of the cellular signal associated with RUNX2 mutations. This evidence concerns the gene RUNX2 and cleidocranial dysplasia 1.