F8 and hemophilia A: In this study, we demonstrated that the F8‐modified ProliHHs obtained a new ability to secrete F8 proteins, and transplantation of the cells could effectively correct the bleeding phenotype in mice with haemophilia A. Similarly, we hypothesize that autologous ProliHHs derived from patients with genetic liver diseases can be corrected or gene‐edited by lentivirus to treat these diseases.