COL1A1 and neoplasm: As shown in Fig. 8A, in these human neoplasms, the macrophage signature correlated with the expression of SNA1, FN1, ACTA2 (αSMA), SPP1 (osteopontin), COL1A1, and VIM, all genes that are specific for active CAFs, indicating that this gene signature is associated with CAF activation.