The role of autophagy on intraneuronal Aβ is supported by a previous study showing that an AD-related amyloid mouse model (APP23+) presenting dysfunctional autophagy due to conditional knockout of Atg7 exhibits a substantial reduction of amyloid plaques but increased intraneuronal Aβ early in the pathology, which might trigger neurodegeneration and memory impairment [85]. This evidence concerns the gene ATG7 and Alzheimer disease.