PSEN1 and Alzheimer disease: In line with our data, a very recent study has shown that Tert transcriptional activation in transgenic 3xTg-AD mice (which carry two FAD mutations together with a mutation of the MAPT gene [88]) reduces abnormal intracellular Aβ staining in the CA1 region and upregulates genes involved in synaptic signaling and neuronal survival [106].