To investigate the impact of telomere-induced senescence on amyloid pathology found in AD, we crossed the Terc−/− mice with the well-described 5xFAD transgenic AD mouse model that expresses human APP and PSEN1 transgenes with a total of five FAD mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1. Four different genotypes were generated to be used in our study: WT mice used as controls, G3Terc−/− mice, 5xFAD mice, and the novel G3Terc−/− 5xFAD mice. This evidence concerns the gene PSEN1 and Alzheimer disease.