Therefore, our study demonstrated that RSGB suppressed the inflammatory response and cell cycle by inhibiting the Tgfβ1/Smad2/3 pathway, Wnt4/β-Catenin pathway and NGFR/NF-κB pathway, thereby exerting an anti-renal fibrosis effect (Fig. 7C). The gene discussed is NFKB1; the disease is renal fibrosis.