In a monosodium iodoacetate (MIA) rat model of osteoarthritis, Lunhao Bai et al. observed a positive correlation between the expression of Ca2+-dependent proteins, calmodulin, and TRPV5 in chondrocytes of osteoarthritis rats, substantiating the hypothesis that TRPV5 is a calmodulin-dependent channel [113]. This evidence concerns the gene TRPV5 and osteoarthritis.