Jinho Lee et al. found that soluble Klotho can anchor TRPV5 on the membrane surface by combining with TRPV5 and the membrane protein Galectin-1, upregulating TRPV5 without FGF23 while preventing the degradation of TRPV5 and endocytosis caused by diabetes [147].A recent report by Miguel Chillón’s team demonstrated that the anti-aging gene α-Klotho produces two major transcript variants, processed Klotho (p-KL) and secreted protein (s-KL), which exert distinct effects on mineral metabolism and bone microstructure [148]. Here, TRPV5 is linked to diabetes mellitus.