On the other hand, there were statistically significant differences in CTSK expression concerning the following variables; histologic grade of tumor (P = 0.000), histologic type of carcinoma (P = 0.000), size of the tumor (P = 0.000), the status of nodal involvement (P = 0.041), distant metastasis (P = 0.009), TNM clinical stage (P = 0.000), and the incidence of recurrence (P = 0.009). The gene discussed is CTSK; the disease is neoplasm.