GSDMD and colorectal carcinoma: Up-regulated Cdk2/cyclin A2 complexes can accelerate GC cell proliferation by promoting the transition from S to G2 phase [10–12].Wu et al. revealed that lipopolysaccharide-induced pyroptosis inhibits CRC tumorigenesis by promoting the expression of GSDMD and N-terminal GSDMD membrane translocation to enhance chemosensitivity of CRC cells to oxaliplatin [13].