We have explored the role and mechanism of miR-210 in postmenopausal osteoporosis in vivo for the first time, but there are still the following limitations: the specific mechanism of miR-210 was obscure because only the VEGF/Notch1 signaling pathway activity was determined after knockdown or overexpression of miR-210, and it is not clear whether miR-210 also plays a role in improving osteoporosis through other signal pathways in this study. Here, VEGFA is linked to postmenopausal osteoporosis.