To screen for metabolites that fuel metabolism in nutrient-deprived PDA cells, we applied the Biolog phenotypic screening platform on 19 human PDA cell lines and 2 immortalized, non-malignant pancreas cell lines (human pancreatic stellate cells and human pancreatic nestin-expressing cells) (Fig. 1a). The gene discussed is NES; the disease is Patent ductus arteriosus.