Consistently, we found that Upp1 was strongly induced in a mouse tumour-derived cell line from the KPC model (p48-cre;LSL-KrasG12D;LSL-Trp53R172H) when cultured with TIF medium30 or implanted as orthotopic allografts, relative to cells cultured in routine medium with high glucose (Extended Data Fig. 9e). This evidence concerns the gene UPP1 and neoplasm.