LRP6 and neoplasm: However, CD4+ TILs that had been stimulated with the bacteria-derived and microbiota-derived peptide pool also recognized several tumour antigens including laminin subunit α5 (LAMA5), low-density lipoprotein receptor-related protein 6 (LRP6) and SIN3A* peptides, as well as the pools of tumour antigens and bacteria-derived and microbiota-derived peptides by proliferation and/or GM-CSF secretion (Fig. 4d).