CD4 and neoplasm: Furthermore, the cytokine and chemokine profile of immunopeptidome-reactive peripheral CD4+ T cells stimulated with the tumour peptide (LRP6) as well as the pool of IPdBPs showed that T cells secreted not only GM-CSF but also several other pro-inflammatory cytokines including IFNγ, TNF and granzyme B (Extended Data Fig. 7c).