When we analysed the association of the EQ-5D-3L usual activity dimension with sex, age, BMI, and genetic polymorphisms of IL-1R1 and IL-1RN, the EQ-5D-3L usual activity dimension had an association with older age (OR = 2.3, 95% CI: 1.2–4.5) and obesity (OR = 3.0, 95% CI: 1.1–8.0). Here, IL1RN is linked to obesity due to melanocortin 4 receptor deficiency.