IL1R1 and osteoarthritis, knee: The main purpose of this study was to investigate the IL-1RN gene variants rs419598, rs9005, and rs315943 and IL-1R1 rs2287047 and also whole genome of the IL-1 gene cluster polymorphism of IL-1β (IL-1R1 and IL-1RN) in primary knee osteoarthritis and its association with clinical findings, severity of knee osteoarthritis and corresponding biomarkers.