In addition, epigenetic silencing of the Th1-type chemokine CXCL9/10 via deposition of H3K27me3 mediated by PRC2 components (EZH2, SUZ12 and EED) impaired T-cell trafficking toward colon tumors, suggesting that PRC2/H3K27me3-mediated Th1-type chemokine silencing is a novel immune evasion mechanism in human colon cancer. The gene discussed is EZH2; the disease is colonic neoplasm.