CXCL2 and Sepsis: However, treatment of BMDMs with I-BET suppressed the expression of TNF-inducible key proinflammatory cytokine (Il1b, Il1a) and chemokine genes (Ccl5, Cxcl10, Cxcl2/3) associated with epigenetic modifications and CpG content and that contribute to sepsis pathogenesis, conferring protection against LPS-induced endotoxic shock and bacteria-induced sepsis [230, 231].