CXCL9 and ovarian neoplasm: Epigenetic modification for T-cell trafficking and PD-L1 checkpoint blockade A study showed that EZH2-mediated H3K27me3 modification and DNMT1-mediated DNA methylation block ovarian tumor production of the Th1-type chemokines CXCL9 and CXCL10 (CXCL9/10) and subsequently enable effector T-cell trafficking to the TME.