By using ChIP–seq and 4C-seq and analyzing published databases, a putative SE for multiple CXCLs located 20 kb upstream from the CXCL gene loci was identified in alcoholic hepatitis (AH) and found to orchestrate TNFα/NF‐κB-induced upregulation of CXCL chemokines (e.g., CXCL1, CXCL6 and CXCL8, related to neutrophil recruitment and infiltration) associated with active histone modifications in liver sinusoidal endothelial cells (LSECs), a major source of CXCL chemokines regulated by the TNFα/NF-κB signaling axis in the liver. The gene discussed is TNF; the disease is alcoholic hepatitis.