Recently, UHRF1 has been identified as a modulator suppressing multiple exacerbating factors in rheumatoid arthritis (RA) and found to contribute to negative feedback mechanisms that suppress multiple pathogenic events in arthritis, including epigenetic silencing of CCL20, a common UHRF1 target gene among cytokine-, RA-, and antiapoptosis-related genes. Here, UHRF1 is linked to rheumatoid arthritis.