CXCR4 and neoplasm: Epigenetic modifications such as the transcriptionally repressive H3K27me3 modification associated with Ccr7 were shown to determine the migratory capacity of distinct DC subsets (migratory conventional DCs vs nonmigratory bone marrow DCs) [257] and affect epigenetic alteration of CCR7 and CXCR4 in tumor cells [258], and the NAD-dependent deacetylase sirtuin 6 (SIRT6) may promote the ability of CXCR4-positive DCs to migrate to the afferent lymph nodes in the development of experimental autoimmune encephalomyelitis (EAE) [259].