Moreover, after chronic differentiation TREM2 mRNA levels positively correlated with M2-marker CD206 in both AD-and CO-derived cells (Fig. 2d) but negatively correlated to M1 marker IL-6 only in CO-derived cells (Fig. 2e) further suggesting that TREM2 modulation in chronic AD- macrophages might be less sensitive to M1-differentiation. The gene discussed is IL6; the disease is Alzheimer disease.