CCL2 and Alzheimer disease: Furthermore, we evaluated the secretion levels of MCP-1 one of the important chemokines that regulate chemotaxis and infiltration of monocytes/macrophages to the site of inflammation and observed that AD-derived cells showed lower MCP-1 levels in M2 vs. M1 macrophages (pAD-M1vs.M2 = 0.008 in acute, pAD-M1vs.M2 = 0.012 in chronic; Fig. 1e; Supplemental Table 4–5).