Interestingly, as reported in Fig. 4m, tumour cells depleted for Hif-1α display a significantly reduced expression of SLC2A1, LDHA and SLC16A3. Moreover, tumour cells cultured in the presence of CoCl2—a known hypoxia-mimicking chemical inducing Hif-1α protein stabilisation (Fig. 4n and Supplementary Fig. S7C)—display a marked induction of SLC2A1, LDHA and PFKFB3 (Fig. 4o), further indicating that this transcription factor contributes to positively modulate glycolysis-related genes altered in BRAF-like PTCs. This evidence concerns the gene PFKFB3 and neoplasm.