Focusing on CpG islands of all metabolic genes differentially expressed between BRAF- and RAS-like tumours (i.e., 459 genes) we found that about 30% of them display significant methylation changes (i.e., 144 genes, of which 48 hyper- and 96 hypomethylated; Supplementary Files S1 and S2). The gene discussed is BRAF; the disease is neoplasm.