BRAF and neoplasm: Thus, considering the mean methylation values and expression levels of each independent gene, we classified these metabolic genes into four clusters (Fig. 2a), focusing on those belonging to cluster 1 (i.e., 28 genes characterised by CpG islands’ hypomethylation paralleled by overexpression in BRAF-like tumours) and cluster 3 (i.e., 37 genes hypermethylated and downregulated in BRAF-like tumours; Supplementary File S2).