Using this approach, we could define three different classes of genes: (1) significantly hypomethylated—and overexpressed—in BRAF-like tumours (Fig. 2c) and, conversely, (2) hypermethylated—and downregulated—in the same tumour subtype (Fig. 2d), and finally (3) highly correlated but not differentially methylated among tumour subtypes (Fig. 2e). This evidence concerns the gene BRAF and neoplasm.