In line with this, both in PTC and ATC, (i) the overexpression of key glucose transporters and glycolytic enzymes (identified herein as hallmark of papillary and anaplastic BRAF-mutated tumours), (ii) their transcriptional repression and (iii) the impairment of glucose uptake and glycolytic flux upon inhibition of MAPK pathway (by targeting B-raf and/or MEK1/2 proteins), indicate that thyroid carcinomas behave similarly to melanoma cells. The gene discussed is MAP2K1; the disease is neoplasm.