PKM and neoplasm: For the expression analysis, we selected glycolysis-related genes (i.e., SLC2A1, SLC16A3, PFKFB3, PKM1, PKM2 and LDHA) (i) being the most overexpressed in BRAF- vs RAS-like tumours, (ii) displaying the highest glycolytic flux’s coefficients according to Tanner and colleagues [49] and (iii) being also unfavourable prognostic markers across multiple tumour types according to The Human Protein Atlas database (https://www.proteinatlas.org/).