We additionally identified two independent ADD risk loci on chromosome 3 near TRANK1 (rs9867455; PRE = 3.49 × 10−8, βRE = −0.0424, I2 = 0) and VWA5B2 (rs9837978; PRE = 3.75 × 10−8, βRE = −0.0526, I2 = 0) that are outside of the maximal linkage disequilibrium (LD) boundary for any known AD risk loci (Fig. 2). This evidence concerns the gene TRANK1 and Alzheimer disease.