PTH and hypercalcemia disease: In contrast, transient signaling is maintained by abaloparatide due to its unstable RG state.158 These results provide potent evidence to support the assumption that the duration of Gs-mediated cAMP production can modulate the balance between anabolic and catabolic effects since less bone resorption and hypercalcemia have been observed by PTHrP than by PTH.159 Although the specific mechanism requires further investigation, these results reveal potential targets for improving PTH1R ligands.