ANGPTL3 and arthritic joint disease: Conversely, promoting chondrogenesis has been demonstrated in numerous preclinical studies to benefit cartilage regeneration and ameliorate arthritis progression.449,450 By screening 6300 proteins secreted by MSCs, Gerwin et al. identified angiopoietin-like 3 (ANGPTL3) as a potent stimulator of chondrogenesis.451 LNA043, a 26-kDa derivative of ANGPTL3, was also synthesized as a novel disease-modifying OA drug candidate by a single anti-proteolysis point mutation in the core carboxy (C)-terminal fibrinogen-like domain of ANGPTL3.